We see more and more applications with drones in sectors such as safety, inspection and logistics. The next major technology leap in road and air transport is unmanned transport. The market for unmanned means of transport is developing rapidly. Ethical, legal and social issues are just as important for a successful market introduction. In various areas Twente contributes to both the technological and social development of unmanned systems. Space53 at Technology Base Twente is the innovation hotspot to test prototypes and push boundaries.